Can i use USB for the data in/out for addressable LED's

No. But you can use any small Arduino-like board, like an Adafruit trinket to control the neopixels. You would have to write some software to be able to tell that Arduino-like board what to do.

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If your goal is to turn on some LEDs, check out the BrightPi kit from PiSupply (https://github.com/PiSupply/Bright-Pi). It is hooked up to pins 2 - 5 but following the instructions allready posted by Charlie Powell you should be able to connect it to I2C-3 instead.

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Somebody just sent this to me, what do you think?

I don't think that does RGBW either.

Low and behold thereโ€™s an RGBW branch :slight_smile: