I was just pondering last night,
Would it be possible to communicate between Octoprint and a printer over I2C instead of Serial? It's less sensitive and faster speeds.
OctoPrint needs to communicate with the printer firmware using a protocol both support. To the best of my knowledge, there are no printer firmware implementations using I2C as the primary communication. If firmware existed, then OctoPrint's communication layer would need a complete rewrite (by a new author/developer).
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Thanks for the clear answer! 