I got the 'hey there is a new GPX plug-in' notification today so I upgraded and am having some odd things happening now. Previously I had modified the Simplify3D start script to get things to work properly with the GPX plug-in, the main change was to comment out the G92 line, see snippet below.
; **** Replicator 2X start.gcode ****
M73 P0 ; Enable build progress
G162 X Y F3000 ; Home XY maximum
G161 Z F1200 ; Home Z minimum
;G92 Z-5 ; Set Z to -5
G1 Z0 ; Move Z to 0
G161 Z F100 ; Home Z slowly
M132 X Y Z ; Recall home offsets
M135 T0 ; Load right extruder offsets
G1 X-130 Y-75 Z30 F9000 ; Move to wait position off table
With the G92 commented out if I canceled a print (from machine) and then started printing it would home the build plate but then drive it all the way down (instead of the up to switch, back off switch, up again slowly). On a whim I uncommented the G92 and it took care of that.
Also, when canceling a print from machine the head goes to the back, left and one of the steppers is still running. I had to use the stop motors button in Octoprint.
From what I could gather the new plug-in clears/resets the axis offsets when a print starts. This seems to have some undesired effects.