What is the problem?
Can't install plugins on Debian Trixie, on amd64.
Manual installation of Octoprint via standard installation instructions
What did you already try to solve it?
tried reinstalling wheel, pip, and setuptools
Have you tried running in safe mode?
Yes, but I can't try to install any third party plugins, so that didn't help.
Did running in safe mode solve the problem?
no.