Octoprint is super slow and no notifications

What is the problem?

For a couple of days, Octoprint is super slow, when I open the WebGUI it takes a couple of seconds just to click on a menu item. Even the hover effect takes 1-2 seconds to appear. There are also no notifications anymore for example if you stopped a print directly on the printer octoprint showed a red box with a warning before. The box however appeared when I disabled some plugins.

What did you already try to solve it?

I updated the OS via SSH and also tried to update any plugins but they were all up to date.

Have you tried running in safe mode?

Yes

Did running in safe mode solve the problem?

No

Systeminfo Bundle

You can download this in OctoPrint's System Information dialog ... no bundle, no support!)

octoprint-systeminfo-20221122195229.zip (75.2 KB)

Additional information about your setup

OctoPrint version, OctoPi version, printer, firmware, browser, operating system, ... as much data as possible
Chrome Browser latest version, Prusa MK3S latest firmware, Windows 10,